Making your LC Method Compatible with Mass Spectrometry
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چکیده
The power of traditional high-performance liquid chromatography with UV detection (HPLC-UV, DAD) can be readily extended by simply coupling a mass spectrometer (MS) to an existing system. In the early years of liquid chromatographic mass spectrometry (LC-MS), this coupling was considered exotic and complex. After more than 15 years of refinement, LC-MS systems are robust and easy to use, and provide specificity unattainable by any other detection scheme. With the increased analytical capability, challenges may be tackled from several different and complementary directions. This Technical Overview provides an overview to the integration of MS into your existing HPLC system, showing the analytical strengths that MS brings and the ease with which it can be added.
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